The “CHARISMA (Cultural Heritage Advanced Research Infrastructures: Synergy for a Multidisciplinary Approach to Conservation/Restoration) project is an integrating activity project which offered free cost access to most advanced EU scientific instrumentations and knowledge, allowing scientists, conservators-restorers and curators to enhance their research. Its program covers joint research, transnational access and networking, with a high-level partnership of twenty-one organizations to provide access to advanced facilities, with development of research and applications on artwork materials finalized to the conservation of cultural heritage and favoring the opening of larger perspective to the heritage conservation activities in Europe.